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Descriptor English: Platelet Glycoprotein GPIIb-IIIa Complex
Descriptor Spanish: Complejo GPIIb-IIIa de Glicoproteína Plaquetaria
Descriptor complejo GPIIb-IIIa de glicoproteína plaquetaria
Entry term(s) integrina alfaIIbbeta3
receptores GPIIb-IIIa
Scope note: Complejo glicoproteico de la membrana plaquetaria, importante en la adhesión y agregación plaquetaria. Es un complejo de integrina que contiene la INTEGRINA ALFAIIB y la INTEGRINA BETA3, que reconoce la secuencia arginina-glicina-ácido aspártico (RGD) presente en varias proteínas adhesivas. Como tal, es un receptor para el FIBRINÓGENO, el FACTOR DE VON WILLEBRAND, las FIBRONECTINAS, la VITRONECTINA y las TROMBOSPONDINAS. Un déficit de GPIIb-IIIa produce la TROMBOASTENIA DE GLANZMANN.
Descriptor Portuguese: Complexo Glicoproteico GPIIb-IIIa de Plaquetas
Descriptor French: Complexe glycoprotéique IIb-IIIa de la membrane plaquettaire
Entry term(s): GPIIb IIIa Receptors
GPIIb-IIIa Receptors
Glycoproteins IIb IIIa
Glycoproteins IIb-IIIa
Integrin alpha IIb beta 3
Integrin alpha-IIb beta-3
Integrin alphaIIbbeta3
Platelet Glycoprotein GPIIb IIIa Complex
Receptors, GPIIb-IIIa
alphaIIbbeta3, Integrin
beta-3, Integrin alpha-IIb
Tree number(s): D12.776.395.550.625.785
D12.776.543.550.625.785
D12.776.543.750.705.408.460.700
D12.776.543.750.705.675.784
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019039
Scope note: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Thrombasthenia
Previous Indexing: Integrins (1992-1995)
Platelet Membrane Glycoproteins (1987-1995)
Public MeSH Note: 1996; see PLATELET MEMBRANE GLYCOPROTEINS 1987-95; INTEGRIN ALPHAIIBBETA3 was indexed under INTEGRINS 1992-95
History Note: 1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995
Entry Version: GPIIB IIIA
Related: Thrombasthenia MeSH
DeCS ID: 32647
Unique ID: D019039
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2013/07/09
Platelet Glycoprotein GPIIb-IIIa Complex - Preferred
Concept UI M0028424
Scope note Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Preferred term Platelet Glycoprotein GPIIb-IIIa Complex
Entry term(s) GPIIb IIIa Receptors
GPIIb-IIIa Receptors
Glycoproteins IIb IIIa
Glycoproteins IIb-IIIa
Integrin alpha IIb beta 3
Integrin alpha-IIb beta-3
Integrin alphaIIbbeta3
Platelet Glycoprotein GPIIb IIIa Complex
Receptors, GPIIb-IIIa
alphaIIbbeta3, Integrin
beta-3, Integrin alpha-IIb



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